Tuesday, May 8, 2018

UK Latest Hepatitis C Reports - New Hep C Drugs Having An Impact On HCV-related Deaths

Hepatitis C in England  2018 report
Working to eliminate hepatitis C as a major public health threat

In case you missed it, Public Health England this month released the latest hepatitis C virus (HCV) reports, which include slide sets with infographics summarizing progress with hepatitis C elimination in England and the UK.

In this report, we summarise the impact of action plans in England to drive down mortality from HCV, reduce the number of new infections, and outline the actions required to make further progress.

HCV-related deaths drop from end stage liver disease and hepatocellular carcinoma 

The first fall in deaths in more than a decade, has been sustained for another year, with a 3% fall in deaths from HCV-related end stage liver disease (ESLD) and hepatocellular carcinoma (HCC) between 2014 and 2016. This suggests that increased treatment (a 19% increase in 2015/16 compared to earlier years, and 56% more in 2016/17 than in 2015/16) with new direct acting antiviral (DAA) drugs, particularly in those with more advanced disease, may be starting to have an impact. Falls have also been observed in liver transplant registrations (43% fall by 2016, when compared to pre-2014 levels) and liver transplants undertaken (25% fall by 2016, when compared to pre-2014 levels) in those where post-hepatitis C cirrhosis is given as the indication for transplant. These falls are encouraging although it is too early to rule out a degree of deferred listing pending assessment of the impact of treatment. Either way, as treatment is rolled out further, the WHO GHSS target for a reduction in HCV-related mortality of 10% by 2020[1] looks within our reach. Despite this, only around one half (52% in 2016) of people who had injected psychoactive drugs sampled in the UAM Survey[4] were aware of their HCV antibody positive status, and this figure has remained relatively stable at this level over the last decade..... 
Begin here..... 

Last updated 4 May 2018
Published 28 July 2014 
4 May 2018 Added Hepatitis C in England report slide set.
26 March 2018 Hepatitis C in England 2018 report, headline table and infographic added.
28 July 2017 Added Hepatitis C in the UK 2017 report and infographic.
15 March 2017 Uploaded latest HCV in England 2017 report
13 October 2016 Added Hepatitis C in the UK: 2016 slide set and Hepatitis C elimination infographic
28 July 2016 Added hepatitis C in the UK 2016 report.
28 August 2015 Added 2015 Hepatitis C in the UK slide set
28 July 2015 Added Hepatitis C UK report 2015 and headlines.
31 July 2014 The 'Hepatitis C in the UK: 2014 PowerPoint slide' has been uploaded.
28 July 2014 First published. 

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