Monday, April 9, 2018

Exercise Might Prevent Cirrhosis in Overweight and Obese Adults

Liver International. 2018;38(3):515-522. 
Learn more about the preventive role of exercise against the development of cirrhosis among overweight or obese adults.

Exercise Might Prevent Cirrhosis in Overweight and Obese Adults
Cheng-Feng Jan; Oswald Ndi Nfor; Jing-Yang Huang; Shu-Yi Hsu; Pei-Chieh Ko; Min-Chen Wu; Chien-Chang Ho; Yung-Po Liaw

Abstract and Introduction
Background & Aims Exercise in overweight patients with liver disease has improved liver enzymes, insulin levels and quality of life. Scientific evidence is incomplete regarding the role of exercise in the prevention of cirrhosis. We investigated the effect of exercise on the occurrence of cirrhosis in obese and overweight adults.

Exercise was assessed using the 2012 Adult Preventive Medical Service dataset while cirrhosis was identified using the National Health Insurance Research Database. All participants were aged 40 years and older. Unconditional logistic regression was used to estimate the odds ratios for cirrhosis.

Overall, 1586 overweight and 1525 obese adults were identified with cirrhosis. Weekly exercise >150 min was significantly protective for cirrhosis in obese men and women. However, exercise <150 min/wk was significantly protective only in men compared to women. For weekly exercise >150 mins, the odds ratio for cirrhosis in obese men and women was 0.701 (95% CI: 0.584–0.841) and 0.736 (95% CI: 0.562–0.964) respectively. The adjusted odds ratios in overweight men and women were 0.734 (95% CI: 0.622–0.866) and 0.503 (CI: 0.37–0.684). For weekly exercise <150 min/wk, overweight and obese men had odds ratios of 0.879 (CI: 0.0.788–0.98) and 0.874 (CI: 0.782–0.977) compared to 0.918 (95% CI: 0.778–1.083) and 0.916 (95% CI: 0.780–1.075) in overweight and obese women respectively.

Moderate exercise might significantly prevent obese and overweight adults from developing cirrhosis. The benefits appear to be greater for persons who exceed the minimum recommendations of 150 min/wk.

Free registration may be required 


  1. Dear Authors of the above study:
    Please post advice on what kind of exercise would be recommended for HCV patients who reached SVR with DAAs, but were already overweight/obese, and already had cirrhosis (F4). How much improvement in liver disease can be expected?
    answer please to:

  2. Articles that you may be interested in:

    Click here to go to Clinical improvement after successful antiviral DAA therapy for hepatitis C

    Click here to go Severe fibrosis improves in most patients after hepatitis C cure but persists in a quarter

    Click here to go to
    What to eat if you have hepatitis C

    Click here to go to
    The Liver Loving Diet - A Must Read For People With HCV Or Liver Disease
    Click here to go to read - Previous research indicates HCV patients who participated in a diet and exercise program lowered their grade of steatosis and remarkably their fibrosis score, according to a study published in Nutrition 2013.
    All my best,