Thursday, April 5, 2018

Hepatitis C - Interferon-free therapy did not increase the risk of liver cancer

Summary with commentary:
No Extra Liver Cancer Risk with Interferon-Free HCV Regimens
by Diana Swift, March 25, 2018
MedPage Today
Earlier suggestions not supported in retrospective study of 857 patients
Successful treatment of cirrhotic patients with hepatitis C virus (HCV) with direct-acting interferon (IFN)-free antiviral therapy did not increase the risk of incident hepatocellular carcinoma (HCC), researchers said, nor was it associated with increased nodule size or number in those diagnosed with HCC.
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Full-Text Article:
Accepted Manuscript
The risk of hepatocellular carcinoma in cirrhotic patients with hepatitis C & sustained viral response: role of the treatment regimen
Hamish Innes, Stephen T. Barclay , Peter C. Hayes, Andrew Fraser , John F. Dillon, Adrian Stanley, Andy Bathgate, Scott A McDonald, David Goldberg, Heather Valerio, Ray Fox, Nick Kennedy, Pete Bramley, Sharon J. Hutchinson

LAY SUMMARY: We examined the risk of liver cancer among 857 patients with cirrhosis in Scotland who received hepatitis C antiviral therapy and achieved a cure. We compared the risk of first-time liver cancer in patients treated with the newest interferon-free regimens, to patients treated with interferon. After accounting for the different characteristics of these two treatment groups, we found no evidence that interferon-free therapy is associated with a higher risk of liver cancer.

Full text article shared by Henry E. Chang via twitter, view article here....

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