Friday, March 24, 2017

Study - Statin use may lead to: Decreased fibrosis and Reduced risk of developing liver cancer

Coverage Of This Study:
Review shows benefits of statin use in patients with chronic liver injury
Statins were cost-effective and generally well-tolerated, and their benefits often outweighed their potential hepatotoxic risk in patients with severe chronic liver injury and a high risk for developing cardiovascular diseases, according to a recent review of statin studies...

Rationale for the use of statins in liver disease
Robert Schierwagen, Frank Erhard Uschner, Fernando Magdaleno, Sabine Klein, Jonel Trebicka
Published 9 March 2017

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Statin drugs are widely used to manage high cholesterol and reduce the risk of cardiovascular disease. But in a new review of more than 50 studies, researchers cite reductions in liver inflammation and improvements in other related factors as reasons why statins make good candidates for treating chronic liver disease. The article is published ahead of print in the American Journal of Physiology—Gastrointestinal and Liver Physiology.

Reducing cholesterol can have a positive effect on many chronic liver disorders, including non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, as well as in biliary disorders. In some studies, the research team found that statins reduced inflammatory molecules that are typically elevated with liver disease and improved inflammation in the endothelium (cells that line the blood vessels). Statin use may also lead to:
  • Decreased fibrosis (hardening or scarring of tissue),
  • Less development of fatty liver,
  • Slowed or halted spread of hepatitis C virus,
  • Improvement of portal hypertension (high blood pressure in the liver's blood vessels),
  • Destruction of existing liver tumor cells, and
  • Reduced risk of developing liver cancer.
The researchers acknowledge that statin drugs can contribute to liver damage in some people, but for people with advanced liver disease, "[s]tatins are cost-effective, generally well-tolerated by patients and the benefits of statin treatment in most patients outweigh their potential hepatotoxic risk."
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Robert Schierwagen et al. Rationale for the use of statins in liver disease, American Journal of Physiology - Gastrointestinal and Liver Physiology (2017). DOI: 10.1152/ajpgi.00441.2016

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