Tuesday, February 15, 2011

Hepatitis C; Human Genome at "Nature"

Good Afternoon Folks,
A few days ago I mentioned Nature.com as a great source for hepatitis c information. The site has just published a series of papers on the Human Genome you may find interesting, I have listed the papers below including the sites free registration link.
Reported @ Nature
Nature originally reported the IL28B gene and its importance to possibly achieving a sustained virological response in patients who undergo HCV therapy . Nature later reported that the same genetic variants are associated with the natural clearance of the genotype 1 hepatitis C virus.
From Duke, which has a "Center for Human Genome Variation -CHGV"
.Human Genome Variation in the News
Personalization of the Treatment of Hepatitis C
Identification of genetic variants (Il28) that strongly predict who will and who will not be cured of virus by the standard of care treatment, opening the way to the personalization of treatment for Hepatitis C and the development of tailored therapies (published in Nature, 2009)Identification of gene variants that predict who will and who will not suffer significant anemia during the standard of care treatment for chronic Hepatitis C, potentially expanding the proportion of patients eligible for treatment (published in Nature, 2010).

The topic today at nature is the "Human Genome", the site has just published a few papers covering the following; what we have learnt about the genome itself , what is still unknown and what we can expect for the near future.
All these articles can be accessed free, after registration, see below.

The Human Genome Project has been around for almost ten years, not until 2001 did we see the first revolution; when the human genome sequence was first published. Another milestone was in 2010 when nature published the "1000 Genomes Project reveals human variation".

The 1000 Genomes Project, a consortium of researchers from more than 75 universities and companies around the world, two years ago embarked on a mission to catalogue genetic variants — small inter-individual differences in specific regions of the genome — that are found in all human populations. Such differences are quite common, the results of the survey revealed, with each person's genome carrying some 250 or 300 so-called 'loss-of-function' mutations that incapacitate the gene in which they occur.

What is the Human Genome Project?
The Human Genome Project (HGP) is an international 13-year effort formally begun in October 1990. The project was planned to last 15 years, but rapid technological advances accelerated the completion to 2003. Project goals were to determine the complete sequence of the 3 billion DNA subunits (bases), identify all human genes, and make them accessible for further biological study. As part of the HGP, parallel sequencing was done for selected model organisms such as the bacterium E. coli to help develop the technology and interpret human gene function. The Department of Energy's Human Genome Program and the National Institutes of Health's National Human Genome Research Institute (NHGRI) together sponsored the U.S. Human Genome Project.
For more information, see About the Human Genome Project.

Nature/Free Registration

You can register free and read the articles at your leisure.
It does take a few minutes to sign up, and will involve a careful selection of menu items. This blogger selected "other" or "student" while navigating the registration process. Remember when you sign up to fill in the additional box : next to each "other" selection. I was prepared to make a payment, one reason why I have put off registering for so long, but registration was free with many articles to view at no cost. However, some articles will need to be purchased before reading.
At nature click on register located on the top corner of the site. If you choose to "subscribe" for full access to the site there is a yearly cost. Click here for free registration.

The Human Genome;

Best is yet to come
Ten years after the human genome was sequenced, its promise is still to be fulfilled.
Nature 470 , 140 ( 10 February 2011 )
The human genome at ten
Nearly a decade on from the completion of the draft sequence of the human genome, researchers should work with the same intensity and focus to apply the results to health.
Nature 464 , 649-650 ( 31 March 2010 )
Initial impact of the sequencing of the human genome Free access
Eric S. Lander
Nature 470 , 187-197 ( 10 February 2011 )
A decade's perspective on DNA sequencing technology Free access
Elaine R. Mardis
Nature 470 , 198-203 ( 10 February 2011 )
Charting a course for genomic medicine from base pairs to bedside Free access
Eric Green
Nature 470 , 204-213 ( 10 February 2011 )

1 comment:

  1. In relation to genomic medicine, the National Institute of Health has come up with a new plan for genomic medicine. Take a look. http://cbt20.wordpress.com/2011/02/21/strategic-plan-genomic-medicine/