Surveillance data presented at the recent 50th Interscience Conference on Antimicrobial Agents and Chemotherapy
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Background:
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Treatment success is relatively low for hepatitis C infections genotype 1.
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Methods:
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Treatment success is relatively low for hepatitis C infections genotype 1.
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Methods:
Data were drawn from cases of HCV infection reported in 2009 to health departments in Connecticut, Minnesota, 34 counties in New York State, and New York ,.
Cases were de-duplicated locally and submitted to CDC as part of an enhanced, population-based surveillance project. .
Standard demographic and select clinical characteristics were collected for each case defined on the basis of a valid value for at least one of the following tests: recombinant immunoblot assay, HCVRNA, screening test positive signal to cut off ratio, or genotype. .
Frequencies of cases were described by site, age, sex, race/ethnicity, and country of birth. .
Results:
How Many Confirmed Cases Of HCV .
A total of 16,620 confirmed cases of HCV infection were reported by the participating sites..
The Four Sites
A total of 16,620 confirmed cases of HCV infection were reported by the 4 sites;
of these, 3,081 (18.5%) had a genotype result. .
Of the 3,081 cases, 62.2% were reported from NYC
20.2% from NYS
15.5% from MN
and 2.1% from CT
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Genotype 1 Was The Most Common at Around 73%,
Geno 1- 73.3% were genotype 1 (range by site 64.6%-77.5%)
Geno 2-11.9% were genotype 2 (10.2%-16.6%)
Geno 3- 11.6% were genotype 3 (8.0%-18.5%)
Geno 4,5, or 6- 3.3% were genotype 4, 5, or 6
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Age Among cases with genotype 3,
A higher percentage was observed among adults aged 18-39 years old (16.6%) compared to those aged 40-59 years old (11.9%) and those aged more then 60 years of age(5.5%)
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Genotype 1 Frequency In Ethnic groups,
The frequency of genotype 1 was highest
among non-Hispanic blacks (90.7%)
followed by Hispanics (78.7%),
and non-Hispanic whites (68.1%). ;
Most Genotypes 1 , 2 , and 3 Where US Born
Most cases with genotypes 1 (87.4%)
2 (81.2%)
3 (70.8%) were US bornl
But most people (71.4%) with genotype 4 and all those with genotype 6 were foreign-born.
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Conclusions: In 2009, there was limited variability in genotype by geographic area, but surveillance is needed as more persons are screened and those with HCV infection are referred for medical care including treatment.
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