Wednesday, October 27, 2010

Sorafenib: Rash

Introduction Sorafenib, an oral multitargeted tyrosine kinase inhibitor, is licensed for the treatment of hepatocellular carcinoma. Rash is one of the most common side effects of its use, generally appearing within days to a few weeks of commencing treatment.

We report the first case of rash appearing nine months after starting treatment with sorafenib.Case presentationA 75-year-old Caucasian man initially presented with asymptomatic transient jaundice. He was diagnosed with Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma after extensive investigation.

He tolerated sorafenib 400mg twice a day before presenting nine months later with a rash, confirmed to be drug-induced.

Conclusions: Sorafenib is a drug of choice in Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma. It can cause protracted rash quite late into treatment.

Successful management of the rash could contribute to achieving stable disease in hepatocellular carcinoma over a significant period of time.

Author: Thomas SarkodiePaul Ross
Credits/Source: Journal of Medical Case Reports 2010, 4:338

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