Media Coverage of this Article
Hepatitis C Cures Lag While New Drugs Wait in the Wings
Newer medications can cure HCV infections
A new analysis reveals a dramatic transformation in the care of patients infected with hepatitis C virus (HCV) as more effective and tolerable medications have become available.
In an analysis of all HCV antiviral treatment regimens (N=107,079) initiated from 1999 through 2015 in the US Veterans Affairs national healthcare system, cure rates increased steadily from 19.2% in 1999 to 36.0% in 2010 before a remarkable increase to 90.5% in 2015. The number of patients achieving sustained virologic response was 1313 in 2010, the last year of the interferon era and increased 5.6-fold to 7377 in 2014 and 21-fold to 28,084 in 2015.
"The introduction of effective direct antiviral agents together with the allocation of appropriate funds and resources allowed the VA healthcare system to treat and cure hepatitis C in unprecedented numbers. In fact, out of approximately 57,500 patients cured of hepatitis C in the VA since 1999, approximately half were cured in a single year in 2015," said. Dr. George Ioannou, senior author of the Alimentary Pharmacology and Therapeutics analysis. "The question is whether we are delivering these medications to the patients who need them and what obstacles there are to treating and curing the majority of hepatitis C infected patients."
March 15, 2017
Medscape Medical News
Dramatic Increase in HCV Cure Rate Among Veterans
Use of direct-acting antiviral drugs (DAAs) has led to a 21-fold increase in the cure rate for hepatitis C virus (HCV) infections among patients treated in the Veterans Affairs (VA) healthcare system between 1999 and 2015, according to a new study.
"Considering that HCV infection is the most common cause of cirrhosis and liver cancer in the VA and the United States, that the beneﬁts of SVR are long-lasting and that HCV clearance reduces the risk of liver cancer by 76% and all-cause mortality by 50%, the potential public health beneﬁts of large-scale HCV treatment are great," write Dr Ioannou and colleagues.
Alimentary Pharmacology and Therapeutics
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Transformation of hepatitis C antiviral treatment in a national healthcare system following the introduction of direct antiviral agents
A. M. Moon,P. K. Green,K. Berry,G. N. Ioannou
First published: 8 March 2017
Highly effective direct antiviral agents (DAAs) for hepatitis C virus (HCV) were introduced recently. Their utilisation has been limited by high cost and low access to care.
To describe the effect of DAAs on HCV treatment and cure rates in the United States Veterans Affairs (VA) national healthcare system.
We identified all HCV antiviral treatment regimens initiated from 1 January 1999 to 31 December 2015 (n = 105 369) in the VA national healthcare system, and determined if they resulted in sustained virological response (SVR).