Published online Jun 28, 2018. doi: 10.3748/wjg.v24.i24.2555
Hepatitis C virus infection in children in the era of direct-acting antiviral
Malgorzata Pawlowska, Malgorzata Sobolewska-Pilarczyk, Krzysztof Domagalski
Core tip: There are more than 11 million hepatitis C virus (HCV)-infected children worldwide. Most new HCV-infected cases have occurred through vertical transmission. Currently, a new era of highly effective direct-acting antiviral agents for the treatment of HCV infection has begun for pediatric patients. The first results of clinical trials with interferon-free therapy are very promising. ESPGHAN developed a position paper for the management of chronic HCV infection in children. Non-invasive methods to measure hepatic fibrosis enable the identification of patients with significant liver fibrosis. This article summarizes the current data on epidemiology, new therapies and non-invasive methods in pediatric patients with HCV infection.
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