Thursday, August 29, 2013

Healio: Frequent coffee, chocolate consumption reduced liver enzymes in HIV/HCV coinfected patients

Frequent coffee, chocolate consumption reduced liver enzymes in HIV/HCV coinfected patients

Carrieri MP. J Hepatol. 2013;doi:10.1016/j.jhep.2013.08.014.

August 29, 2013
Patients coinfected with HIV and HCV who reported eating chocolate daily and drinking three or more cups of coffee a day had lower levels of ALT and AST than those who consumed fewer polyphenol-rich foods in a recent study.

Researchers evaluated data collected from 990 adult patients coinfected with HCV and HIV enrolled in the ANRS CO13 HEPAVIH prospective cohort study. Patients with cirrhosis had follow-up visits every 6 months, while noncirrhotic participants had annual visits, with liver biochemistry assessed at each visit. Participants also responded to annual self-administered questionnaires regarding sociodemographic status and dietary and drug habits.
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Interferon-free regimen shows promise for patients with chronic HCV
August 29, 2013
A 24-week interferon-free regimen of sofosbuvir and ribavirin resulted in a high sustained virologic response rate among hepatitis C virus patients with unfavorable treatment characteristics, according to study results published in JAMA.

"This is another important step toward the realization that direct-acting agents in an interferon-free regimen will transform the field of the treatment of chronic hepatitis C virus," study researcher Anthony S. Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, told Infectious Disease News.
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Besifovir noninferior to entecavir for chronic HBV in phase 2b trial

Lai CL. Gut. 2013;doi:10.1136/gutjnl-2013-305138.

August 28, 2013
Patients with chronic hepatitis B treated with besifovir experienced similar outcomes to entecavir recipients, but often required carnitine supplementation, in a recent study.
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New protease inhibitors showing promise for HIV/HCV coinfection
August 28, 2013
This is an exciting time in the treatment of chronic hepatitis C virus infections. As opposed to the antibiotic pipeline, there are a number of new antiviral agents for treatment of hepatitis C in development that may transform the way these patients are treated.
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