Monday, February 11, 2019

Testosterone in Men With Chronic Hepatitis C Infection and After Hepatitis C Viral Clearance

Corrected Proof
Clinical Infectious Diseases, ciy965, https://doi.org/10.1093/cid/ciy965
Published: 02 February 2019
Testosterone in Men With Chronic Hepatitis C Infection and After Hepatitis C Viral Clearance
We evaluated testosterone levels and the prevalence of low testosterone in a cohort of 327 men with chronic HCV infection (human immunodeficiency virus [HIV] coinfection = 150) and in a subset of 85 men with testosterone levels obtained pre-HCV treatment and after sustained virologic response (SVR). Median follow-up was 36 months.
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Commentary: Healio
Low testosterone persists after HCV clearance
February 11, 2019 
Low levels of free testosterone are common among men with chronic hepatitis C infection following SVR and persist after HCV clearance, according to findings from a prospective, longitudinal cohort study.

“Previous research has shown that low total testosterone (TT), low free testosterone (FT), and elevated sex hormone-binding globulin (SHBG) are extrahepatic manifestations of chronic HCV when compared with healthy controls,” Chloe S. Chaudhury, MD, post-baccalaureate research fellow at the National Institute of Allergy and Infectious Diseases, and colleagues wrote. “There is now a need for studies to examine the effect of HCV and HCV viral clearance on long-term testosterone levels and hypogonadal status.” 

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