Article Source: infohep
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Hepatitis C cure does not improve glucose control in type 2 diabetes
Michael CarterPublished: 07 February 2019
A successful response to HCV therapy does not result in long-term improvements in glucose metabolism for patients with type-2 diabetes, according to US research published in Liver International.
A sustained virological response (SVR) was associated with a short-term improvement in a key marker of glucose control, but these improvements were not sustained in the longer-term and within three years glucose control was comparable between SVR patients and individuals who did not receive any HCV therapy or who had an unsuccessful treatment response.
The investigators found the same results when they restricted their analysis to patients who had a SVR after receiving treatment with direct-acting agents (DAAs). “A number of studies have reported significant decreases in HbA1c [glycosolated haemoglobin] immediately after SVR. In contrast, a recent report found that reductions in HbA1c immediately following successful treatment were not sustained after a mean duration of 2.5 years,” write the authors. “A strength of our longitudinal analysis is that our results allow us to reconcile these apparently conflicting reports.”Read more: http://www.infohep.org/page/3426435/
Abstract: Sustained virological response does not improve long‐term glycaemic control in patients with type 2 diabetes and chronic hepatitis C
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