Severe Steroid-responsive Skin Disorders Related to Ledipasvir and Sofosbuvir for HCV.
Tadokoro T1, Morishita A1, Fujita K1, Oura K1, Sakamoto T1, Nomura T1, Tani J1, Yoneyama H1, Masaki T
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Abstract
Combination therapy with ledipasvir and sofosbuvir (LDV/SOF), direct-acting antiviral agents, is highly effective against hepatitis C virus genotype 1 infection. Although LDV/SOF is safer than conventional treatment, reports have indicated that LDV/SOF was discontinued in certain cases due to severe skin disorders. A 68-year-old woman presented with a rash after starting LDV/SOF treatment. We interrupted LDV/SOF and began the oral administration of prednisolone (PSL). After the rash improved, we re-started LDV/SOF with PSL. After treatment, the rash clearly improved; we checked for a sustained virologic response 12 weeks after treatment. Steroids may therefore be an effective treatment option for controlling the side effects of LDV/SOF.
KEYWORDS:
Case reports; drug eruption; hepatitis C; ledipasvir and sofosbuvir; steroid
PMID: 29279506 DOI: 10.2169/internalmedicine.9744-17
Abstract
Combination therapy with ledipasvir and sofosbuvir (LDV/SOF), direct-acting antiviral agents, is highly effective against hepatitis C virus genotype 1 infection. Although LDV/SOF is safer than conventional treatment, reports have indicated that LDV/SOF was discontinued in certain cases due to severe skin disorders. A 68-year-old woman presented with a rash after starting LDV/SOF treatment. We interrupted LDV/SOF and began the oral administration of prednisolone (PSL). After the rash improved, we re-started LDV/SOF with PSL. After treatment, the rash clearly improved; we checked for a sustained virologic response 12 weeks after treatment. Steroids may therefore be an effective treatment option for controlling the side effects of LDV/SOF.
KEYWORDS:
Case reports; drug eruption; hepatitis C; ledipasvir and sofosbuvir; steroid
PMID: 29279506 DOI: 10.2169/internalmedicine.9744-17
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