Saturday, August 5, 2017

New Treatment Options for Rheumatic Manifestations of HCV

August 04, 2017
New Treatment Options for Rheumatic Manifestations of HCV
Christin L. Melton, ELS 
The recent development of oral interferon (IFN)-free direct-acting antiviral agents (DAAs) has important implications for managing hepatitis C virus (HCV) in patients with rheumatic symptoms. Patients may have preexisting rheumatic disorders at the time of HCV infection or may develop an HCV-related autoimmune disorder that manifests rheumatic symptoms.1 
Most HCV-related extrahepatic manifestations are autoimmune or inflammatory disorders that commonly cause rheumatic symptoms. A high prevalence of patients with HCV experience rheumatic symptoms as the disease progresses. Between 6% and 20% develop arthralgia, which typically arises symmetrically in joints of the knees, back, and fingers; arthralgia of the ankles or elbows is rare.1 Myalgia is less common, affecting 2% to 5% of patients.1
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