Wednesday, November 9, 2016

People with HCV are at risk of chronic kidney disease   

People with HCV are at risk of chronic kidney disease      
News Type: Clinical News
Summary Source - 

Findings from a new literature review show that people with HCV are at a significant risk of experiencing chronic kidney disease (CKD).

The reviewers, from Binzhou Medical University in China, found 12 appropriate longitudinal studies involving 1,972,044 subjects, and 15 cross-sectional studies involving 937,607 people.

Overall effect estimate was remarkably significant in the longitudinal studies (hazard ratio 1.45) in contrast to that in the cross-sectional studies (odds ratio 1.25), with obvious heterogeneity.

HCV infection was also associated with a 1.54-fold increased risk of having prevalent proteinuria. In longitudinal studies with estimated glomerular filtration rate (eGFR) < 60, < 30 and < 15 ml/min/1.73m2, the corresponding hazard ratios were 1.39, 1.79 and 2.30, respectively.

Further grouping of the longitudinal studies by median follow-up time at five years revealed that the effect estimate was reinforced in long-term studies (hazard ratio 1.86) relative to that in short-term studies (1.21).

The reviewers summarized that their findings demonstrate the significant risk of experiencing incident CKD after HCV infection, with the lower eGFR and longer HCV exposure time entailing a greater risk.
Li M, Wang P, Yang C et al. Oncotarget. 2016 Oct 25 [Epub ahead of print]

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