HCV NEXT - Studying Factors Associated With Clearance and Relapse

Monday, October 17, 2016

HCV NEXT - Studying Factors Associated With Clearance and Relapse

Bringing Hepatology to the People: How Community-Based Care Succeeds

HCV Next offers information on a range of liver topics, which include diagnosis, new combination therapies, side effects, drug/drug interaction, guidelines, practice management issues, to name a few.

The following articles appeared in the October print edition of HCV NEXT, provided online at Healio.

Table of Contents
5 Questions
A Conversation With Ryan M. Ford, MD

Cover Story
Bringing Hepatology to the People: How Community-Based Care Succeeds

Editorial
Hepatology-Infectious Disease Collaboration Brings Further Breakthrough

Feature
Making the Case for Studying Factors Associated With Clearance and Relapse

In the Journals
One-Step HCV Diagnostic Shows 99% Specificity, 100% Sensitivity

Combination Regimens Show Similarly High Real-World SVR Rate in VA Cohort

In the Journals Plus

Mortality in HCV Patients After SVR Still Higher Than General Population

Trend Watch
Penn Medicine Trial Investigates Kidney Transplants From HCV-Positive Donors

AASLD/IDSA Recommend HBV Testing in HCV Guidance Update

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Link to research and news articles addressing the high cost of hepatitis C drugs; insurance restrictions - private insurers/Medicaid - and availability of generic versions/India, Egypt and other lower-income countries or through online "buyers clubs"

Latest Update Feb 12, 2019

Lancet Study:

Direct-acting antivirals reduce risk of premature mortality and liver cancer for people with chronic hepatitis C

These findings firmly counter those of a Cochrane review of direct-acting antiviral treatment trials that could neither confirm nor reject if direct-acting antivirals had an effect on long-term HCV-related morbidity and mortality. They also provide the best evidence to date to support guidance documents that recommend direct-acting antiviral treatment for all patients with chronic HCV infection.

The Controversy
Rebuttal over Cochrane Review of DAAs
A systematic review published by the Cochrane Collaboration suggested achieving SVR (cure) for patients using hepatitis C direct-acting antivirals (DAAs) doesn't correlate with any long term benefits. View each rebuttal and all ongoing media coverage.