Friday, July 7, 2017

Treatment of Chronic Hepatitis C with Concomitant Extrahepatic Manifestations Deserves a Closer Look

J Transl Int Med.
doi: 10.1515/jtim-2017-0009
Diagnosis and Treatment of Chronic Hepatitis C with Concomitant Extrahepatic Manifestations Deserves a Closer Look
Xiao-Guang Dou*,1 and Han Bai1

HCV infection and other diseases
In addition to diabetes and kidney diseases, the concomitant extrahepatic manifestations of HCV infection also include thyroid disease and haematological diseases. In recent years, more and more attention has been drawn to the increased risk of morbidity and mortality of cardiovascular diseases, secondary to atherosclerosis caused by HCV infection. However, the mechanism by which HCV infection causes extrahepatic diseases remains unclear, and maybe multifaceted, involving the replication of HCV in extrahepatic cells or increased systemic immune response.

Anti-HCV treatments, especially the use of oral DDAs without Interferon, can benefit patients with extrahepatic manifestations by ameliorating certain concomitant conditions (such as cryoglobulinemia), reducing insulin resistance and occurrence of diabetes or stroke, and improving fatigue and cognitive dysfunction.
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July 12, 2017
Extrahepatic manifestations of HCV: The role of direct acting antivirals
Expert Review of Anti-infective Therapy DOI: 10.1080/14787210.2017.1354697
Introduction: Hepatitis C virus (HCV) represents a major health concern, as nearly 3 million people become newly infected by this pathogen annually. The majority of infected individuals fail to clear the virus, and chronicity is established. Chronic HCV patients are at high risk for liver disease, ranging from mild fibrosis to cirrhosis and severe hepatocellular carcinoma. Over the last few years, the development of multiple direct acting antivirals (DAA) have revolutionized the HCV infection treatment, demonstrating cure rates higher than 90%, and showing less side effects than previous interferon-based regimens. Areas covered: Besides liver, HCV infection affects a variety of organs, therefore inducing diverse extrahepatic manifestations. This review covers clinical, experimental, and epidemiological publications regarding systemic manifestations of HCV, as well as recent studies focused on the effect of DAA in such conditions.  Expert commentary: Though further research is needed; available data suggest that HCV eradication is often associated with the improvement of extrahepatic symptoms. Therefore, the emergence of DAA would offer the opportunity to treat both HCV infection and its systemic manifestations, requiring shorter treatment duration and driving minor adverse effects.
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A collection of research articles on ailments related to HCV

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