By Barbara McGovern, M.D.
April 3, 2012
Daclatasvir was studied along with asunaprevir (an HCV protease inhibitor in development) in a small study of HCV-monoinfected patients who previously didn't respond to PEG interferon plus ribavirin. In results presented at CROI 2012, the use of "quad" (four-drug) therapy consisting of daclatasvir plus asunaprevir plus PEG intereferon plus ribavirin led to cures for 9 of 10 patients. In addition, 4 of 11 patients who only got the two new HCV drugs (i.e., not PEG interferon or ribavirin) were cured of their HCV infection. Although this is a small study to “test out the waters,” these are pretty amazing results. Much larger trials are now planned in HCV-monoinfected patients.
To get ready for future trials in HIV/HCV-coinfected patients, the makers of daclatasvir did three separate studies in healthy volunteers. One study looked at drug interactions between the NRTI Viread (tenofovir) and daclatasvir; another at drug interactions between the NNRTI Sustiva (efavirenz) and daclatasvir; and the last one looked at interactions between daclatasvir and the protease inhibitor Reyataz (atazanavir) boosted with Norvir (ritonavir).....
Continue Reading @ The Body
No comments:
Post a Comment