Hepatitis C,HCC Abstract;A case of light chain deposition disease involving liver and stomach

Case report: A case of light chain deposition disease involving liver and stomach with chronic hepatitis C virus infection and hepatocellular carcinoma

Jung Hee Kwon1, Sook-Hyang Jeong1,*, Jin-Wook Kim1, Soo-Mee Bang1,
Haeryoung Kim2, Young Hoon Kim3, Sang Hoon Song4

Article first published online: 16 MAR 2011

DOI: 10.1002/jmv.22050
Copyright © 2011 Wiley-Liss, Inc.

Keywords:
HCV;HCC;light chain deposition disease;B cell proliferation

Abstract

Light chain deposition disease (LCDD) is a rare, plasma cell proliferative disorder characterized by mainly abnormal light chain deposition in various organs. Hepatitis C virus (HCV) is a hepatotrophic and lymphotrophic virus and significantly related to B-cell proliferation. This is a case report of systemic LCDD involving liver, stomach, bone marrow, and probably kidney, in a patient with HCV-related hepatocellular carcinoma (HCC). A 62-year-old man with chronic HCV infection who presented with a small HCC in segment 8 of the liver and nephrotic syndrome showed kappa typed immunoglobulin light chain depositions in biopsy specimens of bone marrow, stomach, and non-tumorous liver parenchyma. After treatment of the HCC with transarterial chemoembolization, antiviral therapy for chronic hepatitis C was started. The patient showed early virologic response at 12 weeks of treatment; however, antiviral therapy was discontinued due to adverse effects and he was lost to follow-up. This is the first case of LCDD involving the liver and stomach in a patient with chronic HCV infection and HCC, which may represent LCDD as a rare HCV-associated B cell proliferative disease. J. Med. Virol. 83:810–814, 2011. © 2011 Wiley-Liss, Inc.

http://onlinelibrary.wiley.com/doi/10.1002/jmv.22050/abstract