Risk Of Developing Liver Cancer After HCV Treatment

Monday, February 11, 2019

Testosterone in Men With Chronic Hepatitis C Infection and After Hepatitis C Viral Clearance

Updated: 2020 Jan
Infection with hepatitis C virus (HCV) primarily affects the liver, but other organ systems may be affected as well, especially..

We are all getting older, or at least that is my hope for you and me, just not prematurely so.


Research - Archives 2019
Corrected Proof
Clinical Infectious Diseases, ciy965, https://doi.org/10.1093/cid/ciy965
Published: 02 February 2019
Testosterone in Men With Chronic Hepatitis C Infection and After Hepatitis C Viral Clearance
We evaluated testosterone levels and the prevalence of low testosterone in a cohort of 327 men with chronic HCV infection (human immunodeficiency virus [HIV] coinfection = 150) and in a subset of 85 men with testosterone levels obtained pre-HCV treatment and after sustained virologic response (SVR). Median follow-up was 36 months.
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Commentary: Healio
Low testosterone persists after HCV clearance
February 11, 2019 
Low levels of free testosterone are common among men with chronic hepatitis C infection following SVR and persist after HCV clearance, according to findings from a prospective, longitudinal cohort study.

“Previous research has shown that low total testosterone (TT), low free testosterone (FT), and elevated sex hormone-binding globulin (SHBG) are extrahepatic manifestations of chronic HCV when compared with healthy controls,” Chloe S. Chaudhury, MD, post-baccalaureate research fellow at the National Institute of Allergy and Infectious Diseases, and colleagues wrote. “There is now a need for studies to examine the effect of HCV and HCV viral clearance on long-term testosterone levels and hypogonadal status.”

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