Statins: old drugs as new therapy for liver diseases?

Journal of Hepatology

Articles in Press 

Statins: old drugs as new therapy for liver diseases?

Elisa Pose, Jonel Trebicka, Rajeshwar P. Mookerjee, Paolo Angeli, Pere Ginès

DOI: https://doi.org/10.1016/j.jhep.2018.07.019

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Highlights
•Statins have shown potential beneficial effects in chronic inflammatory diseases, including chronic lung diseases, neurological disorders and chronic kidney disease.
•Studies in animal models of liver diseases have shown that statins reduce liver fibrosis, improve endothelial dysfunction and decrease portal pressure.
•In patients with pre-cirrhotic conditions, statins may have beneficial effects by preventing disease progression.
•In patients with cirrhosis, statins have shown potential beneficial effects by decreasing portal hypertension and risk of decompensation and may improve survival.

•RCTs in large series of patients are needed to confirm safety and beneficial effects of statins in patients with cirrhosis.

Read the complete article: https://www.journal-of-hepatology.eu/article/S0168-8278(18)32275-X/fulltext