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Thursday, June 29, 2017

Liver cirrhosis: a risk factor for gallstone disease in chronic hepatitis C patients in China

Research Article: Observational Study
Full Text Article Available Online
Medicine: June 2017 - Volume 96 - Issue 26 - p e7427
doi: 10.1097/MD.0000000000007427

Liver cirrhosis: a risk factor for gallstone disease in chronic hepatitis C patients in China
Li, Xu PhD; Wang, Zhongfeng PhD; Wang, Le MD; Pan, Meng MD; Gao, Pujun PhD*

Abstract: We investigated the possible link between liver cirrhosis and gallstone risk in chronic hepatitis C (CHC) patients in China.

To analyze the association between liver cirrhosis and gallstone development, we compared outcomes of 133 Chinese CHC patients with gallstones and an age-, sex-, and hepatitis C virus RNA level-matched control group of 431 CHC patients without gallstones.

We found that liver cirrhosis was more prevalent in gallstone patients (40.6%) than in the control group (24.4%). Logistic regression analyses adjusting for demographic features and other gallstone risk factors revealed that liver cirrhosis increased the risk of gallstone development 2-fold (adjusted odds ratio [AOR]: 2.122; 95% confidence interval [CI]: 1.408–3.198). Moreover, multivariate analyses comparing the risk of gallstone development in liver cirrhosis patients with decompensated or compensated liver cirrhosis yielded an estimated AOR (95% CI) of 2.869 (1.277–6.450) in patients with decompensated liver cirrhosis. Gallstone risk also increased significantly with older age (>60 years) (AOR: 2.019; 95% CI: 1.017–4.009).

Liver cirrhosis significantly correlates with increased risk of gallstone development in CHC patients in China. Decompensated liver cirrhosis and older age further heighten this risk in patients diagnosed with hepatitis C-related cirrhosis.
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Review Article
Full Text Review Article Available Online
Volume 2017 (2017), Article ID 9749802, 8 pages
https://doi.org/10.1155/2017/9749802

Gallstones in Patients with Chronic Liver Diseases
Xu LiXiaolin GuoHuifan JiGe Yu, and Pujun Gao
With prevalence of 10–20% in adults in developed countries, gallstone disease (GSD) is one of the most prevalent and costly gastrointestinal tract disorders in the world. In addition to gallstone disease, chronic liver disease (CLD) is also an important global public health problem. The reported frequency of gallstone in chronic liver disease tends to be higher. The prevalence of gallstone disease might be related to age, gender, etiology, and severity of liver disease in patients with chronic liver disease. In this review, the aim was to identify the epidemiology, mechanisms, and treatment strategies of gallstone disease in chronic liver disease patients.
Read the article published January 2017 online in BioMed Research International.

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