Foretelling toxicity: FDA researchers work to predict risk of liver injury from drugs

Foretelling toxicity: FDA researchers work to predict risk of liver injury from drugs

Cassandra Willyard1, Journal name: Nature Medicine Volume: 22, Pages:450–451
Year published:(2016) DOI:doi:10.1038/nm0516-450
Published online 05 May 2016

In December 2014, the US Food and Drug Administration (FDA) approved a new drug cocktail, from the Chicago-based pharmaceutical company AbbVie, to treat hepatitis C infection. Less than a year later, the agency warned that the cocktail, Viekira Pak, and another, newer AbbVie hepatitis C therapy could cause serious liver injury in individuals with advanced liver disease. The agency noted that it had received reports of at least 26 cases of liver injuries that might have been caused by the drugs. Of these, ten patients experienced liver failure so severe that they either needed a transplant or died.....

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