HCV/Genotype 1 Enhanced Population In The US

Surveillance data presented at the recent 50th Interscience Conference on Antimicrobial Agents and Chemotherapy

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Background:
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Treatment success is relatively low for hepatitis C infections genotype 1.
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Methods:

Data were drawn from cases of HCV infection reported in 2009 to health departments in Connecticut, Minnesota, 34 counties in New York State, and New York ,.

Cases were de-duplicated locally and submitted to CDC as part of an enhanced, population-based surveillance project. .

Standard demographic and select clinical characteristics were collected for each case defined on the basis of a valid value for at least one of the following tests: recombinant immunoblot assay, HCVRNA, screening test positive signal to cut off ratio, or genotype. .

Frequencies of cases were described by site, age, sex, race/ethnicity, and country of birth. .

Results:

How Many Confirmed Cases Of HCV .

A total of 16,620 confirmed cases of HCV infection were reported by the participating sites..

The Four Sites

A total of 16,620 confirmed cases of HCV infection were reported by the 4 sites;

of these, 3,081 (18.5%) had a genotype result. .

Of the 3,081 cases, 62.2% were reported from NYC

20.2% from NYS

15.5% from MN

and 2.1% from CT

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Genotype 1 Was The Most Common at Around 73%,

Geno 1- 73.3% were genotype 1 (range by site 64.6%-77.5%)

Geno 2-11.9% were genotype 2 (10.2%-16.6%)

Geno 3- 11.6% were genotype 3 (8.0%-18.5%)

Geno 4,5, or 6- 3.3% were genotype 4, 5, or 6

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Age Among cases with genotype 3,

A higher percentage was observed among adults aged 18-39 years old (16.6%) compared to those aged 40-59 years old (11.9%) and those aged more then 60 years of age(5.5%)

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Genotype 1 Frequency In Ethnic groups,

The frequency of genotype 1 was highest

among non-Hispanic blacks (90.7%)

followed by Hispanics (78.7%),

and non-Hispanic whites (68.1%). ;

Most Genotypes 1 , 2 , and 3 Where US Born

Most cases with genotypes 1 (87.4%)

2 (81.2%)

3 (70.8%) were US bornl

But most people (71.4%) with genotype 4 and all those with genotype 6 were foreign-born.

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Conclusions: In 2009, there was limited variability in genotype by geographic area, but surveillance is needed as more persons are screened and those with HCV infection are referred for medical care including treatment.

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http://www.hivandhepatitis.com/2010_conference/icaac/docs/1001_a.html