Volume 43, Issue 5, pages 562–574, March 2016
The most recent issue of the Alimentary Pharmacology & Therapeutics characterized the relationship between coffee consumption and cirrhosis.
Liver cirrhosis is a large burden on global health, causing over one million deaths per year.
Observational studies have reported an inverse association between coffee and cirrhosis.
Dr Kennedy and colleagues from the United Kingdom performed a systematic review and meta-analysis to characterize the relationship between coffee consumption and cirrhosis.
The team searched for studies published until 2015 that reported odds ratios, relative risks or hazard ratios for cirrhosis stratified by coffee consumption.
The researchers calculated relative risks of cirrhosis for an increase in daily coffee consumption of 2 cups for each study and overall.
The team performed analyses by study design, type of cirrhosis and mortality.
The research team assessed the risk of bias in each study, and the overall quality of evidence for the effect of coffee on cirrhosis.
The team identified 5 cohort studies and 4 case–control studies involving 1990 cases and 432,133 participants.
The researchers observed a dose–response in most studies and overall.
The pooled relative risk of cirrhosis for a daily increase in coffee consumption of 2 cups was 0.56.
The relative risk pooled from cohort studies for a daily increase of 2 cups was 0.58, and from case–control studies it was 0.52.
The pooled relative risk of alcoholic cirrhosis for a daily increase of 2 cups was 0.62, and of death from cirrhosis it was 0.55.
Dr Kennedy’s team comments, “This meta-analysis suggests that increasing coffee consumption may substantially reduce the risk of cirrhosis.”
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