Sunday, October 21, 2012

Autoimmune thyroiditis in patients with chronic hepatitis C virus during IFN-alpha therapy


Association between genetic mutations and the development of autoimmune thyroiditis in patients with chronic hepatitis C treated with interferon alpha

Full Article is available in PDF Format

Janina Krupinska, Waldemar Urbanowicz, Mariusz Kaczmarczyk, Grzegorz Kulig, Elżbieta Sowinska-Przepiera, Elżbieta Andrysiak-Mamos and Anhelli Syrenicz

Thyroid Research 2012, 5:10 doi:10.1186/1756-6614-5-10 Published: 16 October 2012
Abstract (provisional)
Background

Considerable progress was made by the introduction of interferon to the treatment of chronic hepatitis C virus infection. This treatment, however, is associated with the risk of developing or exacerbating autoimmune diseases, with chronic autoimmune thyroiditis being one of them. The aim of our study was to evaluate the predisposition to autoimmune thyroiditis in patients with chronic hepatitis C virus during IFN-alpha therapy, depending on the presence of polymorphisms in the promoter region of CTLA-4C (-318)T gene and in exon 1 of A49G gene as well as C1858T transition of PTPN22 gene.
Methods

The study was conducted in 149 patients aged between 18 and 70 years (mean of 43.9 years), including 82 men and 67 women. Control group for the assessment of the distribution of analyzed polymorphism of genotypes consisted of 200 neonates, from whom umbilical blood was drawn for the tests. The patients were divided into three groups: group 1 consisted of 114 patients without thyroid impairment before and during IFN-alpha therapy, group 2 contained 9 patients with AT with the onset prior to IFN-alpha treatment, and group 3 comprised 26 patients with AT starting after the beginning of IFN-alpha therapy.
Results

The frequency of C1858Tand C(-318)T genotypes observed in the study group did not differ significantly from control group. A significant difference, however, was found for A49G polymorphism.
Conclusions

No association was demonstrated between the occurrence of autoimmune thyroiditis with the onset during IFN-alpha therapy and the presence of polymorphisms within CTLA-4 C(-318)T gene in the promoter region and A49G in exon 1, as well as C1858T transition ofPTPN22 gene.

The complete article is available as a provisional PDF.

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