Tuesday, April 17, 2012

Caffeine use may offer relief for millions of dry eye sufferers

The benefits of caffeine in liver disease has long been associated with everything from the response to HCV therapy to lower liver enzyme levels and recently a decreased risk of fibrotic liver disease in NAFLD-nonalcoholic fatty liver disease

Research has also shown that caffeine/coffee may have benefits in  protecting against Parkinson's disease, type 2 diabetes and liver cancer.

People suffering with HCV may have yet another reason to drink coffee, according to researchers at the University of Tokyo's School of Medicine caffeine may advance the treatment of dry eye syndrome. The research team headed by Reiko Arita, MD, PhD, "found that caffeine intake can significantly increase the eye's ability to produce tears."

HCV infection has been associated with several eye disorders, according to this 2009 study hepatitis C patients, especially those with advanced stages of fibrosis, were more likely to exhibit severe ocular surface damage and signs of dry eye. In 2011 researchers concluded that the hepatitis C virus infection causes dry eye, as noted these patients did not undergo therapy. The data also showed -"There was no linear association between time of hepatitis C infection and intensity observed in dry eye tests" click here for the abstract.

In Todays News

Caffeine use may offer relief for millions of dry eye sufferers
Study published in Ophthalmology journal


SAN FRANCISCO – April 17, 2012 – Researchers at the University of Tokyo's School of Medicine have shown for the first time that caffeine intake can significantly increase the eye's ability to produce tears, a finding that could improve treatment of dry eye syndrome. This common eye condition affects about four million people age 50 and older in the United States. For many, dry eye syndrome is simply uncomfortable and annoying, but for others it escalates into a vision-threatening disease. All of the 78 participants in the new study produced significantly more tears after consuming caffeine than after taking a placebo. The study is available in Ophthalmology, the journal of the American Academy of Ophthalmology.

Dry eye syndrome involves malfunction of the rate of tear production, the quality of tears, and/or the rate of evaporate from the surface of the eye. Anyone can experience dry eye, though it is more common among women. Symptoms can include gritty, scratchy or burning sensations, excessive tearing, and/or production of stringy mucus.

The research team, by Reiko Arita, MD, PhD, was motivated by an earlier study that had shown a reduced risk for dry eye in caffeine users: 13 percent of users had the syndrome compared with nearly 17 percent of non-users. The team knew that caffeine was likely to stimulate tear glands, since it is known to increase other secretions, such as saliva and digestive juices. They also knew that people respond differently to caffeine, so they analyzed study participants' DNA samples for two genetic variations that play important roles in caffeine metabolism. Tear production proved to be higher in study subjects who had the two genetic variations.

"If confirmed by other studies, our findings on caffeine should be useful in treating dry eye syndrome," said Dr. Arita. "At this point, though, we would advise using it selectively for patients who are most sensitive to caffeine's stimulating effects."

The study subjects were divided into two groups: one received caffeine tablets in the first session and a placebo in the second session, while the order was reversed for the other group. Tear volume was measured within 45 minutes of consuming the tablets. All sessions took place between 10 a.m. and noon, a time of day when tear production is usually stable. No subjects knew whether they received caffeine or the placebo. All abstained from caffeine use for six days prior to each session and used no drugs during the sessions. To be eligible for the study subjects had to be free of high blood pressure, dry eye syndrome, allergies that affect the eye, glaucoma, and other eye diseases and conditions that can interfere with tear production. The study also found that tear drainage rates were not affected by caffeine.

Dry eye can be very uncomfortable and interfere with vision. It's important to see an ophthalmologist if symptoms continue, since advanced cases can cause eye damage and permanent vision problems. Current treatment options range from simple warm compresses, eye washes and artificial tears to medications and tear drainage devices.

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Note to media: Contact Media Relations to request full text of the study, arrange interviews with experts, and request images.

About the American Academy of Ophthalmology
The American Academy of Ophthalmology is the world's largest association of eye physicians and surgeons — Eye M.D.s — with more than 32,000 members worldwide. Eye health care is provided by the three "O's" – ophthalmologists, optometrists, and opticians. It is the ophthalmologist, or Eye M.D., who can treat it all: eye diseases, infections and injuries, and perform eye surgery. For more information, visit www.aao.org. The Academy's EyeSmart® public education program works to educate the public about the importance of eye health and to empower them to preserve their healthy vision, by providing the most trusted and medically accurate information about eye diseases, conditions and injuries. Visit www.geteyesmart.org to learn more.

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